![]() |
Interleukin-1&4: Features, Production, Biological functions, Medical uses, side effects |
Interleukin-1&4:
Features, Production, Biological functions, Medical uses, side effects
Features
of Interleukin-1:
1.
Lymphocyte activating factor (LAF)
2.
Endogenous pyrogen, catabolin.
3. Two forms
are - Interleukin-1 alpha and beta.
The genes coding for them reside on human
chromosome 2.
4. Sources
of Interleukin-1 are macrophages, T and B cells.
Biological
functions of Interleukin-1:
1.
Stimulation of T and B cells with additional cytokines.
2. Helps
neutrophils in chemotaxis
3. Promotes
phagocytes
4. Promotes
the synthesis of various substances such as proteases and other enzymes
involved in generating inflammatory mediators.
5. Induces synthesis
of acute phase proteins in hepatocytes along with interleukin-
6. It acts
as a co-stimulator of hematopoietic cell growth.
Medical
uses of Interleukin-1 for these clinical indications:
a.
Immunostimulatory effects
b. Ability
to protect the hematopoietic process during chemotherapy.
c.
Anti-proliferative effects against various human tumor cell lines grown in
vitro.
d.
Bone-marrow suppression by chemotherapy
e. Various
cancers
f. Kineret
in rheumatoid arthritis
Side-effects
of Interleukin-1:
Hypotension,
Capillary leakage syndrome.
Features:
B cell stimulating factor.
129 amino acids glycoprotein.
Source - Th2 cells, basophills, mast cells, NK cells.
Functions:
1. Promotes proliferation of B cells
2. Induction of Th2 cells, stimulation of cytotoxic T
cells.
3. stimulation of NK cell activity.
4. Antibody IgE class switching in B cells.
5. Promotes growth of mast cells with IL 3
6. Upregulation of class 2 MHC expression on B cells.
7. Roles in tissue adhesion and inflammation.
8. Macrophage activation, together with IL-3 that promotes phagocytes.
Uses:
1. Induction of immediate hypersensitivity (allergic)
reactions through these processes -
a) Induction of
IgE synthesis - mediator of allergic reaction.
b) promotes congregation of monocytes and eosinophils,
they contain inflammatory mediators.
c) its growth promoting effect on mast cells.
"Interleukin-1&4:
Features, Production, Biological functions, Medical uses, side effects"
Written By
Sadia
Akhtar
Student of
Department of Microbiology
Jagannath
University.
Email-
sadiabd810@yahoo.com
0 Comments