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JAK - STAT Pathway |
JAK
- STAT Pathway
Full form:
Janus - Kinase Signal Transducer and Activator of Transcription Pathway
Definition:
It is a pathway that transmits information from
chemical signals outside the cell, which
causes DNA transcription and other activity in the cell.
Components:
3 main components -
a. A receptor
b. Janus - Kinase (JAK)
c. Signal Transducer and Activator of Transcription
(STAT)
Mechanism:
1. JAK has tyrosine kinase activity, binds to some
cell surface cytokine receptors.
2. The binding of the ligand to the receptor triggers
activation of JAKs.
3. With increased kinase activity, they phosphorylate
tyrosine residues on the receptor.
STATs possessing SH2 domains are recruited to the
receptors.
4. Then they are tyrosine phosphorylated by JAKs on
the receptors.
5. Activated STAT dimers accumulate in the cell
nucleus and activate transcription of their target genes.
6. STATs may also be tyrosine phosphorylated directly
by receptor tyrosine kinases, such as the epidermal growth factor receptor as
well as by non-receptor tyrosine kinases.
7. Activated STATs regulate expression of IFN and
other cytokine-sensitive genes.
The Daily Youth- tdy24.com Presents
" JAK - STAT Pathway"
Written By
Sadia Akhtar
Student of Department of Microbiology
Jagannath University.
Email- sadiabd810@yahoo.com
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